Cholinergic Inhibition of Neocortical Pyramidal Neurons
نویسندگان
چکیده
منابع مشابه
Cholinergic inhibition of neocortical pyramidal neurons.
Acetylcholine (ACh) is a central neurotransmitter critical for normal cognitive function. Here we show that transient muscarinic acetylcholine receptor activation directly inhibits neocortical layer 5 pyramidal neurons. Using whole-cell and cell-attached recordings from neurons in slices of rat somatosensory cortex, we demonstrate that transient activation of M1-type muscarinic receptors induce...
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ACh release into the rodent prefrontal cortex is predictive of successful performance of cue detection tasks, yet the cellular mechanisms underlying cholinergic modulation of cortical function are not fully understood. Prolonged ("tonic") muscarinic ACh receptor (mAChR) activation increases the excitability of cortical pyramidal neurons, whereas transient ("phasic") mAChR activation generates i...
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In the neocortex, the coexistence of temporally locked excitation and inhibition governs complex network activity underlying cognitive functions, and is believed to be altered in several brain diseases. Here we show that this equilibrium can be unlocked by increased activity of layer 5 pyramidal neurons of the mouse neocortex. Somatic depolarization or short bursts of action potentials of layer...
متن کاملRAPID COMMUNICATION Muscarinic Inhibition of Persistent Na Current in Rat Neocortical Pyramidal Neurons
Mittmann, Thomas and Christian Alzheimer. Muscarinic inhibibuffered oxygenated saline solution containing 19 U/ml papain. Whole cell currents were evoked and recorded using an Axopatch tion of persistent Na current in rat neocortical pyramidal neurons. J. Neurophysiol. 79: 1579–1582, 1998. Muscarinic modulation of 200 amplifier in conjunction with a TL-1 interface and pClamp 6.0 software (all f...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2005
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.2697-05.2005